Can I permanently remove custom profile fields from all reports in the platform?

You can request that one or more of your custom profile fields be disabled and excluded from both quick and custom reports so that they no longer appear and so that the reports can no longer be filtered by them. If you wish to have one or more of your custom profile fields excluded from reports in your platform, please reach out to your Customer Success Manager and they will have them excluded. 

For more information, see Disabling custom profile fields in reports.